Doctors call physical exercise a “polypill,” because it can prevent and treat many of the chronic diseases that are associated with aging. A new study of muscle fibers from mice and humans shows how exercise affects gene expression. The exercise-induced changes “reprogram” the epigenetic expression of the fibers to a more youthful state. The findings could provide leads for the development of drugs to mimic these benefits in people who are unable to exercise. Research shows that people who...

Time-restricted eating (TRE) limits when people can eat during the day to a window of between 8 to 10 hours. Proven benefits of the diet include improvements in sleep, overweight and obesity, blood glucose regulation, cardiac function, and gut health. A recent study in mice found that time-restricted feeding (TRF) affects the expression of genes in multiple tissues, including the gut and brain. The study also adds to evidence that time-restricted feeding may promote longevity and have...