Brian S. Appleby, MD | Source | Professor and National Prion Disease Pathology Surveillance Center at Case We...
Brian S. Appleby, MD
Brian is a Neuropsychiatrist at University Hospitals Cleveland Medical Center who treats and researches cognitive disorders. Dr. Appleby is an Associate Professor of neurology, psychiatry, and pathology at Case Western Reserve University and University Hospitals Cleveland Medical Center, the National Prion Disease Pathology Surveillance Center Director, and Medical Director of the Creutzfeldt-Jakob (CJD) Foundation. He is also Chair of the Cleveland Chapter Alzheimer's Association Professional Advisory Board.
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Case Western Reserve University
Professor and National Prion Disease Pathology Surveillance Center
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NIH researchers never said there is no risk of CWD spillover to humans
Some news stories on a recentstudy finding a strong chronic wasting disease (CWD) species barrier between cervids such as deer and humans have concluded that there is no risk of a zoonotic spillover of the fatal prion disease.
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They weren’t able to transmit chronic wasting disease to these human cerebral organoids, but that's not a human. And there are so many other factors that go into transmission outside of such experimental spaces. It is encouraging in that it emphasizes that at least with current CWD strains, there is a high species barrier, but it certainly doesn't mean that [spillover] isn't possible or that the threshold of the species barrier might not change in the future when CWD strains evolve.
