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Dr. Mark Horowitz, MD, PhD

Scientific Co-Founder at Outro
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Dr. Horowitz is a neuroscientist, Clinical Research Fellow in Psychiatry at the National Health Service in England, and a world-leading researcher in psychiatric medication deprescribing. Mark co-wrote the Royal College of Psychiatrists' guidelines on antidepressant discontinuation, based on the principle of gradual, hyperbolic tapering. His firsthand experience of the difficulty of coming off antidepressants, the lack of professional support, and the help he received through peer support websites inspired him to pursue research and clinical work in safe deprescribing of psychiatric drugs. He co-founded Outro Health to give others the professional support he was unable to find for himself.

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  • “The hyperbolic [i.e., ultra slow] tapering method Outro uses places significant emphasis on careful monitoring of symptoms, high responsiveness to increasing withdrawal symptoms, and careful titration of the rate of reduction based on symptoms, all in the context of easily accessible support from experts trained by leaders in the field. In this way, excessively quick dose reductions are avoided.”

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