Key takeaways Bupropion is the generic form of Wellbutrin, an antidepressant commonly prescribed to treat depression and various mental health conditions and to aid in smoking cessation. Bupropion often starts working within the first two weeks of use but may show full effects after a longer period. Factors such as food, medication, age, and health conditions can affect how fast this medication works and its effectiveness. In this article: How long does it take bupropion to work? Influencing...